FOS monoclonal antibody, clone RM374
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human FOS.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to N-terminus of human FOS.
Reactivity
Human
Specificity
This antibody reacts to human Proto-oncogene c-Fos. It may also react to mouse and rat c-Fos, as predicted by immunogen homology.
Form
Liquid
Purification
Protein A purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:500-1000)
Western Blot (1:1000-5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol, 1% BSA, 0.09% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot (Cell lysate) analysis of HeLa cell lysates.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human thyroid. -
Gene Info — FOS
Entrez GeneID
2353Gene Name
FOS
Gene Alias
AP-1, C-FOS
Gene Description
v-fos FBJ murine osteosarcoma viral oncogene homolog
Omim ID
164810Gene Ontology
HyperlinkGene Summary
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq
Other Designations
FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)|activator protein 1|cellular oncogene c-fos
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Interactome
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Disease
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