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IP6K2 monoclonal antibody, clone 4F10

  • Catalog # : MAB2177
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against full length recombinant IP6K2.
  • Immunogen:
  • Recombinant protein corresponding to full length human IP6K2.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • This antibody recognizes human IP6K2.
  • Form:
  • Liquid
  • Isotype:
  • IgG2b
  • Quality Control Testing:
  • Antibody Reactive Against Recombinant Protein.
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Effect of gamma-irradiation and IFN-beta on IP6K2 protein levels.
    (a) NIH:OVCAR-3 cells growing at 75% confluence were trypsinized, suspended in 1 ml PBS, and subject to 0, 1 (white bars) or 2 Gy (gray bars) irradiation and replated in complete medium.
    At 8 and 16 h after plating, cells were lysed and subject to Western blot analysis using IP6K2 monoclonal antibody, clone 4F10 (Cat # MAB2177).
    To control for loading, blots were probed with anti-actin antibody; bands were digitized and quantified.
    IP6K2 signal intensity was normalized to actin, then expressed as fold induction, with unirradiated cells representing a protein level of 1.
    Purified rIP6K2 was included as a positive control (lane 1).
    Numbers to right of blots indicate MW markers.
    Only relevant portion of the blots are shown.
    (b) NIH-OVAR-3 cells were grown in the presence of 200 U/ml IFN-beta for 0-48 h and then subject to Western blot analysis and quantified as above.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Gene Information
  • Gene Name:
  • IP6K2
  • Gene Alias:
  • IHPK2,PiUS
  • Gene Description:
  • inositol hexakisphosphate kinase 2
  • Gene Summary:
  • This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
  • Other Designations:
  • ATP:1D-myo-inositol-hexakisphosphate phosphotransferase,OTTHUMP00000164824,Pi uptake stimulator,inositol hexaphosphate kinase 2,insP6 kinase 2
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