F8 monoclonal antibody, clone F827.4
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Specifications
Product Description
Mouse monoclonal antibody raised against native F8.
Immunogen
Native purified human F8.
Host
Mouse
Reactivity
Human
Specificity
Recognizes the 83kD light chain of Factor VIII. These antibodies do not cross-react with von Willebrand factor.
Form
Liquid
Isotype
IgG2a
Quality Control Testing
Antibody Reactive Against Native Purified Protein.
Recommend Usage
ELISA (1:16000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — F8
Entrez GeneID
2157Gene Name
F8
Gene Alias
AHF, DXS1253E, F8B, F8C, FVIII, HEMA
Gene Description
coagulation factor VIII, procoagulant component
Omim ID
306700Gene Ontology
HyperlinkGene Summary
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq
Other Designations
OTTHUMP00000061446|OTTHUMP00000196174|coagulation factor VIII|coagulation factor VIIIc|factor VIII F8B|procoagulant component
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Interactomes
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Pathways
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Diseases
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