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Pan PRKC (phospho gamma T514) monoclonal antibody, clone PF4 

  • Catalog # : MAB21667
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against synthetic phosphopeptide of human Pan PRKC.
  • Immunogen:
  • A synthetic phosphopeptide corresponding to residues surrounding T514 of human PRKCG.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Protein A/G purification
  • Isotype:
  • IgG1, kappa
  • Recommend Usage:
  • Flow Cytometry
    Western Blot
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (50% glycerol, 0.1% BSA and 0.02% sodium azide).
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western Blot analysis of NIH3T3 cell lysate with Pan PRKC (phospho gamma T514) monoclonal antibody, clone PF4 (Cat # MAB21667). Lane 1: untreated or Lane 2: treated with TPA.
  • Flow Cytometry
  • Flow Cytometry
  • Flow cytometric analysis of HT1080 cells with Pan PRKC (phospho gamma T514) monoclonal antibody, clone PF4 (Cat # MAB21667). Treated with staurosporine and stained with the secondary antibody only as negative control (blue) or treated with staurosporine (red) or untreated (green).
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 5578
  • Protein Accession#:
  • P17252;P05771;P05771-2;Q05655;Q02156;P24723;P05129;Q04759
  • Gene Name:
  • PRKCA
  • Gene Alias:
  • AAG6,MGC129900,MGC129901,PKC-alpha,PKCA,PRKACA
  • Gene Description:
  • protein kinase C, alpha
  • Gene Summary:
  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq
  • Other Designations:
  • aging-associated gene 6,protein kinase C alpha type
  • Gene Information
  • Entrez GeneID:
  • 5579
  • Protein Accession#:
  • P17252;P05771;P05771-2;Q05655;Q02156;P24723;P05129;Q04759
  • Gene Name:
  • PRKCB
  • Gene Alias:
  • MGC41878,PKC-beta,PKCB,PRKCB1,PRKCB2
  • Gene Description:
  • protein kinase C, beta
  • Gene Summary:
  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
  • Other Designations:
  • protein kinase C, beta 1 polypeptide
  • Gene Information
  • Entrez GeneID:
  • 5580
  • Protein Accession#:
  • P17252;P05771;P05771-2;Q05655;Q02156;P24723;P05129;Q04759
  • Gene Name:
  • PRKCD
  • Gene Alias:
  • MAY1,MGC49908,PKCD,nPKC-delta
  • Gene Description:
  • protein kinase C, delta
  • Gene Summary:
  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq
  • Other Designations:
  • protein kinase C delta VIII
  • Gene Information
  • Entrez GeneID:
  • 5581
  • Protein Accession#:
  • P17252;P05771;P05771-2;Q05655;Q02156;P24723;P05129;Q04759
  • Gene Name:
  • PRKCE
  • Gene Alias:
  • MGC125656,MGC125657,PKCE,nPKC-epsilon
  • Gene Description:
  • protein kinase C, epsilon
  • Gene Summary:
  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq
  • Other Designations:
  • -
  • Gene Information
  • Entrez GeneID:
  • 5583
  • Protein Accession#:
  • P17252;P05771;P05771-2;Q05655;Q02156;P24723;P05129;Q04759
  • Gene Name:
  • PRKCH
  • Gene Alias:
  • MGC26269,MGC5363,PKC-L,PKCL,PRKCL,nPKC-eta
  • Gene Description:
  • protein kinase C, eta
  • Gene Summary:
  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. [provided by RefSeq
  • Other Designations:
  • protein kinase C eta type
  • Gene Information
  • Entrez GeneID:
  • 5582
  • Protein Accession#:
  • P17252;P05771;P05771-2;Q05655;Q02156;P24723;P05129;Q04759
  • Gene Name:
  • PRKCG
  • Gene Alias:
  • MGC57564,PKC-gamma,PKCC,PKCG,SCA14
  • Gene Description:
  • protein kinase C, gamma
  • Gene Summary:
  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). [provided by RefSeq
  • Other Designations:
  • -
  • Gene Information
  • Entrez GeneID:
  • 5588
  • Protein Accession#:
  • P17252;P05771;P05771-2;Q05655;Q02156;P24723;P05129;Q04759
  • Gene Name:
  • PRKCQ
  • Gene Alias:
  • MGC126514,MGC141919,PRKCT,nPKC-theta
  • Gene Description:
  • protein kinase C, theta
  • Gene Summary:
  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000019053,OTTHUMP00000043364,OTTHUMP00000043365
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