RB1 monoclonal antibody, clone 7F12
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant RB1.
Immunogen
Recombinant protein corresponding to amino acids 280-330 of RB1.
Host
Mouse
Reactivity
Human
Specificity
This antibody recognizes an epitope within aa 280-330 of RB1.
Form
Liquid
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS, pH 7.4
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — RB1
Entrez GeneID
5925Gene Name
RB1
Gene Alias
OSRC, RB, p105-Rb, pRb, pp110
Gene Description
retinoblastoma 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq
Other Designations
OTTHUMP00000018397|retinoblastoma suspectibility protein|retinoblastoma-associated protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Retinoblastoma protein monoclonal antibodies with novel characteristics.
S F Wen, M Nodelman, K Nared-Hood, J Duncan, J Geradts, H M Shepard.
Journal of Immunological Methods 1994 Mar; 169(2):231.
Application:ELISA, Flow Cyt, IHC-P, IP, WB-Ce, Human, Mouse, A-549, H146, H209, H596, HeLa, Human bladder carcinoma, Human prostatic adenocarcinoma, SK-OV-3 cells, Recombinant proteins.
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Retinoblastoma protein monoclonal antibodies with novel characteristics.
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