BLNK (phospho Y84) monoclonal antibody, clone H4 (SureLight 488)
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More Files
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Flow Cytometry
Flow cytometric analysis of Ramos cells with BLNK (phospho Y84) monoclonal antibody, clone H4 (SureLight 488) (Cat # MAB21629). Unstained and untreated cells as negative control (blue) or untreated and stained (red) or treated with INFa+IL-4 +pervanadate and stained (green).
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic phosphopeptide of human BLNK.
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Y84 of human BLNK.
Host
Rabbit
Reactivity
Human
Form
Liquid
Conjugation
SureLight 488
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (5 uL/106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.2% BSA, 0.09% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of Ramos cells with BLNK (phospho Y84) monoclonal antibody, clone H4 (SureLight 488) (Cat # MAB21629). Unstained and untreated cells as negative control (blue) or untreated and stained (red) or treated with INFa+IL-4 +pervanadate and stained (green). -
Gene Info — BLNK
Entrez GeneID
29760Protein Accession#
Q8WV28Gene Name
BLNK
Gene Alias
BASH, BLNK-S, LY57, MGC111051, SLP-65, SLP65
Gene Description
B-cell linker
Omim ID
604515Gene Ontology
HyperlinkGene Summary
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
B cell linker protein|B-cell adapter containing a SH2 domain protein|B-cell adapter containing a Src homology 2 domain protein|OTTHUMP00000020167|Src homology 2 domain-containing leukocyte protein of 65 kDa
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Interactome
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Pathway
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Disease
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