PTEN (phospho S380/T382/T383) monoclonal antibody, clone E4 (PE)
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More Files
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Flow Cytometry
Flow cytometric analysis of A431 cells with PTEN (phospho S380/T382/T383) monoclonal antibody, clone E4 (PE) (Cat # MAB21600). Untreated and unstained cells as negative control (blue) or untreated and stained (green) or treated with lambda phosphatase and stained (red).
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic phosphopeptide of human PTEN.
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding S380/T382/T383 of human PTEN.
Host
Rabbit
Reactivity
Human
Form
Liquid
Conjugation
PE
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (5 uL/106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.2% BSA, 0.09% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of A431 cells with PTEN (phospho S380/T382/T383) monoclonal antibody, clone E4 (PE) (Cat # MAB21600). Untreated and unstained cells as negative control (blue) or untreated and stained (green) or treated with lambda phosphatase and stained (red). -
Gene Info — PTEN
Entrez GeneID
5728Protein Accession#
P60484Gene Name
PTEN
Gene Alias
10q23del, BZS, MGC11227, MHAM, MMAC1, PTEN1, TEP1
Gene Description
phosphatase and tensin homolog
Gene Ontology
HyperlinkGene Summary
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq
Other Designations
MMAC1 phosphatase and tensin homolog deleted on chromosome 10|OTTHUMP00000020032|mutated in multiple advanced cancers 1
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Interactome
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Pathway
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Disease
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