IL6ST monoclonal antibody, clone 8D4C5
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of Lane 1: HEK293 and Lane 2: IL6ST-hIgGFc transfected HEK293 cell lysates with IL6ST monoclonal antibody, clone 8D4C5 (Cat # MAB21510).
Enzyme-linked Immunoabsorbent Assay
ELISA analysis with IL6ST monoclonal antibody, clone 8D4C5 (Cat # MAB21510).
Flow Cytometry
Flow cytometric analysis of HL-60 cells with IL6ST monoclonal antibody, clone 8D4C5 (Cat # MAB21510) (Green). Red: Negative Control.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human IL6ST.
Immunogen
Recombinant protein corresponding to amino acids 73-231 of human IL6ST.
Host
Mouse
Theoretical MW (kDa)
103.5
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Flow Cytometry (1:200-1:400)
Immunocytochemistry (1:200-1:1000)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of Lane 1: HEK293 and Lane 2: IL6ST-hIgGFc transfected HEK293 cell lysates with IL6ST monoclonal antibody, clone 8D4C5 (Cat # MAB21510).Immunocytochemistry
Enzyme-linked Immunoabsorbent Assay
ELISA analysis with IL6ST monoclonal antibody, clone 8D4C5 (Cat # MAB21510).Flow Cytometry
Flow cytometric analysis of HL-60 cells with IL6ST monoclonal antibody, clone 8D4C5 (Cat # MAB21510) (Green). Red: Negative Control. -
Gene Info — IL6ST
Entrez GeneID
3572Protein Accession#
P40189Gene Name
IL6ST
Gene Alias
CD130, CDw130, GP130, GP130-RAPS, IL6R-beta
Gene Description
interleukin 6 signal transducer (gp130, oncostatin M receptor)
Omim ID
600694Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq
Other Designations
CD130 antigen|IL6ST nirs variant 3|OTTHUMP00000122545|gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form|gp130 transducer chain|interleukin 6 signal transducer|interleukin receptor beta chain|membrane glycoprotein gp130|oncostatin M
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Interactome
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Pathway
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Disease
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