IDH2 monoclonal antibody, clone 3E8E9
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human colon cancer with IDH2 monoclonal antibody, clone 3E8E9 (Cat # MAB21490).
Enzyme-linked Immunoabsorbent Assay
ELISA analysis with IDH2 monoclonal antibody, clone 3E8E9 (Cat # MAB21490).
Flow Cytometry
Flow cytometric analysis of HeLa cells with IDH2 monoclonal antibody, clone 3E8E9 (Cat # MAB21490) (Green). Red: Negative Control.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human IDH2.
Immunogen
Recombinant protein corresponding to amino acids 1-143 of human IDH2.
Host
Mouse
Theoretical MW (kDa)
50.9
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Flow Cytometry (1:200-1:400)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-1:1000)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human colon cancer with IDH2 monoclonal antibody, clone 3E8E9 (Cat # MAB21490).Enzyme-linked Immunoabsorbent Assay
ELISA analysis with IDH2 monoclonal antibody, clone 3E8E9 (Cat # MAB21490).Flow Cytometry
Flow cytometric analysis of HeLa cells with IDH2 monoclonal antibody, clone 3E8E9 (Cat # MAB21490) (Green). Red: Negative Control. -
Gene Info — IDH2
Entrez GeneID
3418Protein Accession#
P48735Gene Name
IDH2
Gene Alias
ICD-M, IDH, IDHM, IDP, IDPM, mNADP-IDH
Gene Description
isocitrate dehydrogenase 2 (NADP+), mitochondrial
Omim ID
147650Gene Ontology
HyperlinkGene Summary
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. [provided by RefSeq
Other Designations
NADP+-specific ICDH|isocitrate dehydrogenase, mitochondrial|oxalosuccinate decarboxylase
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Interactome
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Pathway
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of alkaloids derived from ornithine
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of alkaloids derived from terpenoid and polyketide
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Biosynthesis of terpenoids and steroids
- Citrate cycle (TCA cycle)
- Glutathione metabolism
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