TLR3 monoclonal antibody, clone 6F3G4
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human TLR3.
Immunogen
Recombinant protein corresponding to amino acids 24-217 of human TLR3.
Host
Mouse
Theoretical MW (kDa)
103.8
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Flow Cytometry (1:200-1:400)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of Lane 1: HEK293 and Lane 2: TLR3-hIgGFc transfected HEK293 cell lysates with TLR3 monoclonal antibody, clone 6F3G4 (Cat # MAB21479).Enzyme-linked Immunoabsorbent Assay
ELISA analysis with TLR3 monoclonal antibody, clone 6F3G4 (Cat # MAB21479).Flow Cytometry
Flow cytometric analysis of HL-60 cells with TLR3 monoclonal antibody, clone 6F3G4 (Cat # MAB21479) (Green). Red: Negative Control. -
Gene Info — TLR3
Entrez GeneID
7098Protein Accession#
O15455Gene Name
TLR3
Gene Alias
CD283
Gene Description
toll-like receptor 3
Omim ID
603029Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq
Other Designations
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