IGF2R monoclonal antibody, clone 7B5E10
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human IGF2R.
Immunogen
Recombinant protein corresponding to amino acids 160-311 of human IGF2R.
Host
Mouse
Theoretical MW (kDa)
274
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of Lane 1: HEK293 and Lane 2: IGF2R-hIgGFc transfected HEK293 cell lysates with IGF2R monoclonal antibody, clone 7B5E10 (Cat # MAB21466).Enzyme-linked Immunoabsorbent Assay
ELISA analysis with IGF2R monoclonal antibody, clone 7B5E10 (Cat # MAB21466). -
Gene Info — IGF2R
Entrez GeneID
3482Protein Accession#
P11717Gene Name
IGF2R
Gene Alias
CD222, CIMPR, M6P-R, MPR1, MPRI
Gene Description
insulin-like growth factor 2 receptor
Omim ID
147280Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a receptor for both, insulin-like growth factor 2 (IGF2) and mannose 6-phosphate (M6P). The IGF2 and M6P binding sites are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of IGF2. In mice, the homologous gene is expressed only from the maternal chromosome. [provided by RefSeq
Other Designations
OTTHUMP00000017536|cation-independent mannose-6 phosphate receptor|insulin-like growth factor-2 receptor (mannose-6-phosphate receptor, cation-independent)
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