TLR9 monoclonal antibody, clone 5B10E8
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human TLR9.
Immunogen
Recombinant protein corresponding to amino acids 26-193 of human TLR9.
Host
Mouse
Theoretical MW (kDa)
116
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Flow Cytometry (1:200-1:400)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of Lane 1: HEK293 and Lane 2: TLR9-hIgGFc transfected HEK293 cell lysates with TLR9 monoclonal antibody, clone 5B10E8 (Cat # MAB21457).Enzyme-linked Immunoabsorbent Assay
ELISA analysis with TLR9 monoclonal antibody, clone 5B10E8 (Cat # MAB21457).Flow Cytometry
Flow cytometric analysis of HL-60 cells with TLR9 monoclonal antibody, clone 5B10E8 (Cat # MAB21457) (Green). Red: Negative Control. -
Gene Info — TLR9
Entrez GeneID
54106Protein Accession#
Q9NR96Gene Name
TLR9
Gene Alias
CD289
Gene Description
toll-like receptor 9
Omim ID
605474Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Disease
- Adenocarcinoma
- Anemia
- Arthritis
- Arthropathy
- Aspergillosis
- Asthma
- Atherosclerosis
- Behcet Syndrome
- Birth Weight
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