ATXN1 monoclonal antibody, clone 4C7B11
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human ATXN1.
Immunogen
Recombinant protein corresponding to amino acids 645-815 of human ATXN1.
Host
Mouse
Theoretical MW (kDa)
86.9
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Flow Cytometry (1:200-1:400)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-1:1000)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of Lane 1: HEK293 and Lane 2: ATXN1-hIgGFc transfected HEK293 cell lysates with ATXN1 monoclonal antibody, clone 4C7B11 (Cat # MAB21432).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human endometrium cancer with ATXN1 monoclonal antibody, clone 4C7B11 (Cat # MAB21432).Enzyme-linked Immunoabsorbent Assay
ELISA analysis with ATXN1 monoclonal antibody, clone 4C7B11 (Cat # MAB21432).Flow Cytometry
Flow cytometric analysis of Jurkat cells with ATXN1 monoclonal antibody, clone 4C7B11 (Cat # MAB21432) (Green). Red: Negative Control. -
Gene Info — ATXN1
Entrez GeneID
6310Protein Accession#
P54253Gene Name
ATXN1
Gene Alias
ATX1, D6S504E, SCA1
Gene Description
ataxin 1
Gene Ontology
HyperlinkGene Summary
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 41-81 CAG repeats, compared to 6-39 in the normal allele. At least two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000016065|OTTHUMP00000039306|olivopontocerebellar ataxia 1, autosomal dominant|spinocerebellar ataxia 1 (olivopontocerebellar ataxia 1, autosomal dominant, ataxin 1)
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Interactome
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Disease
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