IL5RA monoclonal antibody, clone 5E12F5D6
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human IL5RA.
Immunogen
Recombinant protein corresponding to amino acids 21-196 of human IL5RA.
Host
Mouse
Theoretical MW (kDa)
47.7
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Flow Cytometry (1:200-1:400)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of Lane 1: HEK293 and Lane 2: IL5RA-hIgGFc transfected HEK293 cell lysates with IL5RA monoclonal antibody, clone 5E12F5D6 (Cat # MAB21428).Enzyme-linked Immunoabsorbent Assay
ELISA analysis with IL5RA monoclonal antibody, clone 5E12F5D6 (Cat # MAB21428).Flow Cytometry
Flow cytometric analysis of HL-60 cells with IL5RA monoclonal antibody, clone 5E12F5D6 (Cat # MAB21428) (Green). Red: Negative Control. -
Gene Info — IL5RA
Entrez GeneID
3568Protein Accession#
Q01344Gene Name
IL5RA
Gene Alias
CD125, CDw125, HSIL5R3, IL5R, MGC26560
Gene Description
interleukin 5 receptor, alpha
Omim ID
147851Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported. [provided by RefSeq
Other Designations
CD125 antigen|OTTHUMP00000115257|OTTHUMP00000115373|interleukin 5 receptor type 3|interleukin-5 receptor alpha chain|interleukin-5 receptor alpha subunit
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Interactome
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Pathway
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Disease
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