KIR2DL4 monoclonal antibody, clone 2E3E12
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human KIR2DL4.
Immunogen
Recombinant protein corresponding to amino acids 22-120 of human KIR2DL4.
Host
Mouse
Theoretical MW (kDa)
41.5
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Flow Cytometry (1:200-1:400)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of Lane 1: HEK293 and Lane 2: KIR2DL4-hIgGFc transfected HEK293 cell lysates with KIR2DL4 monoclonal antibody, clone 2E3E12 (Cat # MAB21404).Enzyme-linked Immunoabsorbent Assay
ELISA analysis with KIR2DL4 monoclonal antibody, clone 2E3E12 (Cat # MAB21404).Flow Cytometry
Flow cytometric analysis of HL-60 cells with KIR2DL4 monoclonal antibody, clone 2E3E12 (Cat # MAB21404) (Green). Red: Negative Control. -
Gene Info — KIR2DL4
Entrez GeneID
3805Protein Accession#
Q99706Gene Name
KIR2DL4
Gene Alias
CD158D, G9P, KIR103, KIR103AS
Gene Description
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
Omim ID
604945Gene Ontology
HyperlinkGene Summary
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
NK cell receptor|OTTHUMP00000068610|natural killer cell inhibitory receptor
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Interactome
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Disease
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