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KIR2DL4 monoclonal antibody, clone 4C2D11 

  • Catalog # : MAB21403
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against partial recombinant human KIR2DL4.
  • Immunogen:
  • Recombinant protein corresponding to amino acids 22-120 of human KIR2DL4.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 41.5
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Recommend Usage:
  • ELISA (1:10000)
    Flow Cytometry (1:200-1:400)
    Western Blot (1:500-1:2000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.05% sodium azide).
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • Western Blot analysis of Lane 1: HEK293 and Lane 2: KIR2DL4-hIgGFc transfected HEK293 cell lysates with KIR2DL4 monoclonal antibody, clone 4C2D11 (Cat # MAB21403).
  • Enzyme-linked Immunoabsorbent Assay
  • Enzyme-linked Immunoabsorbent Assay
  • ELISA analysis with KIR2DL4 monoclonal antibody, clone 4C2D11 (Cat # MAB21403).
  • Flow Cytometry
  • Flow Cytometry
  • Flow cytometric analysis of HL-60 cells with KIR2DL4 monoclonal antibody, clone 4C2D11 (Cat # MAB21403) (Green). Red: Negative Control.
  • Application Image
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • enlarge
  • Enzyme-linked Immunoabsorbent Assay
  • Enzyme-linked Immunoabsorbent Assay
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 3805
  • Gene Name:
  • KIR2DL4
  • Gene Alias:
  • CD158D,G9P,KIR103,KIR103AS
  • Gene Description:
  • killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
  • Gene Summary:
  • Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants. [provided by RefSeq
  • Other Designations:
  • NK cell receptor,OTTHUMP00000068610,natural killer cell inhibitory receptor
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