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Last updated: 2021/6/13

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MSR1 monoclonal antibody, clone 5B8H4 

  • Catalog # : MAB21365
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against partial recombinant human MSR1.
  • Immunogen:
  • Recombinant protein corresponding to amino acids 275-451 of human MSR1.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 49.8
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Recommend Usage:
  • ELISA (1:10000)
    Flow Cytometry (1:200-1:400)
    Western Blot (1:500-1:2000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.05% sodium azide).
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • Western Blot analysis of Lane 1: HEK293 and Lane 2: MSR1-hIgGFc transfected HEK293 cell lysates with MSR1 monoclonal antibody, clone 5B8H4 (Cat # MAB21365).
  • Enzyme-linked Immunoabsorbent Assay
  • Enzyme-linked Immunoabsorbent Assay
  • ELISA analysis with MSR1 monoclonal antibody, clone 5B8H4 (Cat # MAB21365).
  • Flow Cytometry
  • Flow Cytometry
  • Flow cytometric analysis of HL-60 cells with MSR1 monoclonal antibody, clone 5B8H4 (Cat # MAB21365) (Green). Red: Negative Control.
  • Application Image
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • enlarge
  • Enzyme-linked Immunoabsorbent Assay
  • Enzyme-linked Immunoabsorbent Assay
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 4481
  • Gene Name:
  • MSR1
  • Gene Alias:
  • CD204,SCARA1,SR-A,phSR1,phSR2
  • Gene Description:
  • macrophage scavenger receptor 1
  • Gene Summary:
  • This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000120049,OTTHUMP00000120050,macrophage acetylated LDL receptor I and II,macrophage scavenger receptor type III,scavenger receptor class A, member 1
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