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HLA-DR monoclonal antibody, clone TAL 1B5 

  • Catalog # : MAB21230
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against human HLA-DR.
  • Immunogen:
  • Monoclonal antibody raised against Bristol 8 cell line of human origin.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Protein A/G purification
  • Isotype:
  • IgG1, kappa
  • Recommend Usage:
  • Flow Cytometry (1-2 ug/106 cells)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
    Western Blot (1-2 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 10 mM PBS.
  • Storage Instruction:
  • Store at -20 to -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • Molecular Weight of antigen: 36 kDa (alpha chain); 27 kDa (beta chain); 63 kDa (HLA-DR dimer).
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western Blot Analysis of Ramos cell lysates.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human lung cancer with HLA-DR monoclonal antibody, clone TAL 1B5 (Cat # MAB21230).
  • Flow Cytometry
  • Flow Cytometry
  • Flow Cytometric Analysis of Raji cells with Cat # MAB21230 followed by goat anti-Mouse IgG-CF488 (Blue); Isotype control (Red).
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 3122
  • Gene Name:
  • HLA-DRA
  • Gene Alias:
  • HLA-DRA1
  • Gene Description:
  • major histocompatibility complex, class II, DR alpha
  • Gene Summary:
  • HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq
  • Other Designations:
  • HLA class II histocompatibility antigen, DR alpha chain,MHC cell surface glycoprotein,histocompatibility antigen HLA-DR alpha
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