HLA-DR monoclonal antibody, clone TAL 1B5
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Specification
Product Description
Mouse monoclonal antibody raised against human HLA-DR.
Immunogen
Monoclonal antibody raised against Bristol 8 cell line of human origin.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (1-2 ug/106 cells)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
Molecular Weight of antigen: 36 kDa (alpha chain); 27 kDa (beta chain); 63 kDa (HLA-DR dimer).
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Applications
Western Blot (Cell lysate)
Western Blot Analysis of Ramos cell lysates.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human lung cancer with HLA-DR monoclonal antibody, clone TAL 1B5 (Cat # MAB21230).Flow Cytometry
Flow cytometric analysis of Raji cells with Cat # MAB21230 followed by goat anti-Mouse IgG-CF488 (Blue) and Isotype control (Red). -
Gene Info — HLA-DRA
Entrez GeneID
3122Protein Accession#
P01903Gene Name
HLA-DRA
Gene Alias
HLA-DRA1
Gene Description
major histocompatibility complex, class II, DR alpha
Omim ID
142860Gene Ontology
HyperlinkGene Summary
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq
Other Designations
HLA class II histocompatibility antigen, DR alpha chain|MHC cell surface glycoprotein|histocompatibility antigen HLA-DR alpha
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