NRG1 monoclonal antibody, clone NRG1/2752
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human NRG1.
Immunogen
Recombinant protein corresponding to amino acids 21-242 of human NRG1.
Host
Mouse
Theoretical MW (kDa)
26-71
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG
Recommend Usage
ELISA
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
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Gene Info — NRG1
Entrez GeneID
3084Protein Accession#
Q02297Gene Name
NRG1
Gene Alias
ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, NDF, SMDF
Gene Description
neuregulin 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD). [provided by RefSeq
Other Designations
glial growth factor|heregulin, alpha (45kD, ERBB2 p185-activator)|neu differentiation factor|neuregulin 1 isoform HRG-gamma|sensory and motor neuron derived factor
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Interactome
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Pathway
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Disease
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