GAD1 monoclonal antibody, clone GAD1/2391
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human GAD1.
Immunogen
Recombinant protein corresponding to amino acids 72-135 of human GAD1.
Host
Mouse
Theoretical MW (kDa)
67
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
ELISA
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human brain with GAD1 monoclonal antibody, clone GAD1/2391 (Cat # MAB21200).Enzyme-linked Immunoabsorbent Assay
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Gene Info — GAD1
Entrez GeneID
2571Protein Accession#
Q99259Gene Name
GAD1
Gene Alias
FLJ45882, GAD, SCP
Gene Description
glutamate decarboxylase 1 (brain, 67kDa)
Gene Ontology
HyperlinkGene Summary
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq
Other Designations
OTTHUMP00000041055|glutamate decarboxylase 1|glutamate decarboxylase 1 (brain, 67kD)
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Interactome
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Disease
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