GAD2 monoclonal antibody, clone GAD2/1960
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human GAD2.
Immunogen
Recombinant protein corresponding to amino acids 6-99 of human GAD2.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG2b, kappa
Recommend Usage
ELISA
Immunohistochemistry (Formalin-fixed) (1-2 ug/mL)
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human Pancreas using GAD2 monoclonal antibody, clone GAD2/1960.Enzyme-linked Immunoabsorbent Assay
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Gene Info — GAD2
Entrez GeneID
2572Protein Accession#
Q05329Gene Name
GAD2
Gene Alias
GAD65, MGC161605, MGC161607
Gene Description
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
Omim ID
138275Gene Ontology
HyperlinkGene Summary
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq
Other Designations
Glutamate decarboxylase-2 (pancreas)|OTTHUMP00000019335|OTTHUMP00000019336|glutamate decarboxylase 2|glutamate decarboxylase 2 (pancreatic islets and brain, 65kD)
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Interactome
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Disease
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