PYCARD monoclonal antibody, clone FFB-16
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot analysis of U937 cell lysate with PYCARD monoclonal antibody, clone FFB-16 (Cat # MAB20793).
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of human PYCARD.
Immunogen
A synthetic peptide corresponding to human PYCARD.
Host
Rabbit
Theoretical MW (kDa)
21.627
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Flow Cytometry (1:50)
Immunocytochemistry (1:50-1:200)
Immunofluorescence (1:50-1:200)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction
Store at -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of U937 cell lysate with PYCARD monoclonal antibody, clone FFB-16 (Cat # MAB20793).Immunocytochemistry
Immunofluorescence
Flow Cytometry
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Gene Info — PYCARD
Entrez GeneID
29108Protein Accession#
Q9ULZ3Gene Name
PYCARD
Gene Alias
ASC, CARD5, MGC10332, TMS, TMS-1, TMS1
Gene Description
PYD and CARD domain containing
Omim ID
606838Gene Ontology
HyperlinkGene Summary
This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
apoptosis-associated speck-like protein containing a CARD|caspase recruitment domain protein 5|target of methylation-induced silencing-1
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Interactome
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Disease
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