TIMP1 monoclonal antibody, clone AOOI-20
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of human TIMP1.
Immunogen
A synthetic peptide corresponding to human TIMP1.
Host
Rabbit
Theoretical MW (kDa)
23.171
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:50-1:200)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction
Store at -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of HL60 cell lysate treated with TPA with TIMP1 monoclonal antibody, clone AOOI-20 (Cat # MAB20785).Immunohistochemistry
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Gene Info — TIMP1
Entrez GeneID
7076Protein Accession#
P01033Gene Name
TIMP1
Gene Alias
CLGI, EPA, EPO, FLJ90373, HCI, TIMP
Gene Description
TIMP metallopeptidase inhibitor 1
Omim ID
305370Gene Ontology
HyperlinkGene Summary
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq
Other Designations
OTTHUMP00000023214|erythroid potentiating activity|fibroblast collagenase inhibitor|tissue inhibitor of metalloproteinase 1
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Interactome
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Disease
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