RPE65 monoclonal antibody, clone ABAH-18
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More Files
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Western Blot (Tissue lysate)
Western Blot analysis of mouse eyeball tissue lysate with RPE65 monoclonal antibody, clone ABAH-18 (Cat # MAB20681).
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of human RPE65.
Immunogen
A synthetic peptide corresponding to human RPE65.
Host
Rabbit
Theoretical MW (kDa)
60.948
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunoprecipitation (1:50)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction
Store at -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western Blot analysis of mouse eyeball tissue lysate with RPE65 monoclonal antibody, clone ABAH-18 (Cat # MAB20681).Immunoprecipitation
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Gene Info — RPE65
Entrez GeneID
6121Protein Accession#
Q16518Gene Name
RPE65
Gene Alias
LCA2, RP20, mRPE65, rd12, sRPE65
Gene Description
retinal pigment epithelium-specific protein 65kDa
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa. [provided by RefSeq
Other Designations
OTTHUMP00000010788|RBP-binding membrane protein|p63|retinal pigment epithelium-specific 61 kDa protein|retinal pigment epithelium-specific protein (65kD)|retinitis pigmentosa 20 (autosomal recessive)
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Interactome
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Pathway
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Disease
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