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Last updated: 2021/8/8

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RPE65 monoclonal antibody, clone ABAH-18 

  • Catalog # : MAB20681
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against synthetic peptide of human RPE65.
  • Immunogen:
  • A synthetic peptide corresponding to human RPE65.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 60.948
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Affinity purification
  • Isotype:
  • IgG
  • Recommend Usage:
  • Immunoprecipitation (1:50)
    Western Blot (1:500-1:2000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
  • Storage Instruction:
  • Store at -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • Western Blot analysis of mouse eyeball tissue lysate with RPE65 monoclonal antibody, clone ABAH-18 (Cat # MAB20681).
  • Immunoprecipitation
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Immunoprecipitation
  • Gene Information
  • Entrez GeneID:
  • 6121
  • Gene Name:
  • RPE65
  • Gene Alias:
  • LCA2,RP20,mRPE65,rd12,sRPE65
  • Gene Description:
  • retinal pigment epithelium-specific protein 65kDa
  • Gene Summary:
  • This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000010788,RBP-binding membrane protein,p63,retinal pigment epithelium-specific 61 kDa protein,retinal pigment epithelium-specific protein (65kD),retinitis pigmentosa 20 (autosomal recessive)
  • Gene Pathway
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