CFLAR monoclonal antibody, clone AT8B12
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant CFLAR.
Immunogen
Recombinant protein corresponding to amino acids 1-480 of human CFLAR.
Host
Mouse
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Protein G purification
Isotype
IgG1, kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
ELISA
Immunocytochemistry
Immunofluorescence
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (10% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of Lane 1: Jurkat cell lysate, Lane 2: HeLa cell lysate, Lane 3: MCF7 cell lysate, Lane4: K562 cell lysate.Immunocytochemistry
Immunofluorescence
Immunofluorescence analysis of HeLa cells. The cell was stained with CFLAR monoclonal antibody, clone AT8B12 (1:100). The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue).Enzyme-linked Immunoabsorbent Assay
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Gene Info — CFLAR
Entrez GeneID
8837Protein Accession#
NP_003870Gene Name
CFLAR
Gene Alias
CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS
Gene Description
CASP8 and FADD-like apoptosis regulator
Omim ID
603599Gene Ontology
HyperlinkOther Designations
FADD-like anti-apoptotic molecule|caspase-related inducer of apoptosis|inhibitor of FLICE|usurpin beta
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Interactome
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Pathway
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Disease
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Publication Reference
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FLIP and the death effector domain family.
Yu JW, Shi Y.
Oncogene 2008 Oct; 27(48):6216.
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IL-2-mediated apoptosis of kidney tubular epithelial cells is regulated by the caspase-8 inhibitor c-FLIP.
Du C, Guan Q, Yin Z, Zhong R, Jevnikar AM.
Kidney International 2005 Apr; 67(4):1397.
Application:WB-Tr, Mouse, Mouse tubular epithelial cells.
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FLIP and the death effector domain family.
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