Cell lysates of HeLa (lane 1), MCF-7 (lane 2), LNCaP (lane 3) and mouse brain (lane 4) (30 ug) were resolved by SDS-PAGE and probed with TREM2 monoclonal antibody, clone 2B5 (Cat # MAB2056) (1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
The protein encoded by this gene is a membrane protein that forms a receptor signaling complex with TYROBP. The encoded protein may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). [provided by RefSeq
OTTHUMP00000016368,OTTHUMP00000039771,triggering receptor expressed on monocytes 2,triggering receptor expressed on myeloid cells 2a