Cell lysates of HeLa (lane 1) and 293T (lane 2) (20 ug) were resolved by SDS-PAGE and probed with EPM2A monoclonal antibody, clone k2A3 (Cat # MAB2052) (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
This gene encodes a dual-specificity phosphatase that associates with polyribosomes. The encoded protein may be involved in the regulation of glycogen metabolism. Mutations in this gene have been associated with myoclonic epilepsy of Lafora. Alternative splicing results in multiple transcript variants. [provided by RefSeq
OTTHUMP00000017360,epilepsy, progressive myoclonus type 2, Lafora disease (laforin),laforin