LDLR monoclonal antibody, clone BFC-12
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of human LDLR.
Immunogen
A synthetic peptide corresponding to human LDLR.
Host
Rabbit
Theoretical MW (kDa)
95.376
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1:1000-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction
Store at -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of HepG2 cell lysate with LDLR monoclonal antibody, clone BFC-12 (Cat # MAB20443). -
Gene Info — LDLR
Entrez GeneID
3949Protein Accession#
P01130Gene Name
LDLR
Gene Alias
FH, FHC
Gene Description
low density lipoprotein receptor
Gene Ontology
HyperlinkGene Summary
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. [provided by RefSeq
Other Designations
LDL receptor|low-density lipoprotein receptor class A domain-containing protein 3
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Interactome
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Disease
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