PPARGC1A monoclonal antibody, clone AOBC-16
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of human PPARGC1A.
Immunogen
A synthetic peptide corresponding to human PPARGC1A.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Instruction
Store at -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of (1) HeLa cell lysate; (2) NIH/3T3 cell lysate; (3) C6 cell lysate with PPARGC1A monoclonal antibody. -
Gene Info — PPARGC1A
Entrez GeneID
10891Protein Accession#
Q9UBK2Gene Name
PPARGC1A
Gene Alias
LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1
Gene Description
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
Omim ID
604517Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq
Other Designations
OTTHUMP00000123372|PPAR gamma coactivator variant form|PPAR gamma coactivator-1|ligand effect modulator-6|peroxisome proliferative activated receptor, gamma, coactivator 1, alpha
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Interactome
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Disease
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