CDKN2D monoclonal antibody, clone DCS-100
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant CDKN2D.
Immunogen
Recombinant protein corresponding to full length human CDKN2D.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry
Immunoprecipitation
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Gene Info — CDKN2D
Entrez GeneID
1032Gene Name
CDKN2D
Gene Alias
INK4D, p19, p19-INK4D
Gene Description
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
Omim ID
600927Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq
Other Designations
CDK inhibitor p19INK4d|cell cycle inhibitor, Nur77 associating protein|cyclin-dependent kinase 4 inhibitor D p19|cyclin-dependent kinase inhibitor 2D|inhibitor of cyclin-dependent kinase 4d
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Interactome
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Pathway
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Disease
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Publication Reference
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Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6.
Hirai H, Roussel MF, Kato JY, Ashmun RA, Sherr CJ.
Molecular and Cellular Biology 1995 May; 15(5):2672.
Application:IP, WB-Re, Mouse, BAC1.2F5, NIH/3T3 cells, Recombinant protein.
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Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6.
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