MSH6 monoclonal antibody, clone AEB-13
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of human MSH6.
Immunogen
A synthetic peptide corresponding to human MSH6.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunocytochemistry (1:50-1:200)
Immunofluorescence (1:50-1:200)
Immunohistochemistry (1:50-1:200)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Instruction
Store at -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of SW480 cell lysate with MSH6 monoclonal antibody.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of paraffin-embedded human colon with MSH6 monoclonal antibody.Immunocytochemistry
Immunofluorescence
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Gene Info — MSH6
Entrez GeneID
2956Protein Accession#
P52701Gene Name
MSH6
Gene Alias
GTBP, HNPCC5, HSAP
Gene Description
mutS homolog 6 (E. coli)
Omim ID
600678Gene Ontology
HyperlinkGene Summary
This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer. [provided by RefSeq
Other Designations
G/T mismatch-binding protein|mutS homolog 6|sperm-associated protein
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Interactome
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Pathway
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Disease
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