SMC1A monoclonal antibody, clone C2M
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot (Cell lysate)
Western blotting using SMC1A monoclonal antibody, clone C2M (Cat # MAB2014) on HeLa cell lysate at 1 ug/mL .
-
Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant SMC1A.
Immunogen
Recombinant protein corresponding to amino acids 402-894 of human SMC1A.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
Western blot (1 to 5 ug/mL)
Immunofluorescence (5 to 10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Cell lysate)
Western blotting using SMC1A monoclonal antibody, clone C2M (Cat # MAB2014) on HeLa cell lysate at 1 ug/mL .Immunofluorescence
-
Gene Info — SMC1A
Entrez GeneID
8243Gene Name
SMC1A
Gene Alias
CDLS2, DKFZp686L19178, DXS423E, KIAA0178, MGC138332, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB
Gene Description
structural maintenance of chromosomes 1A
Gene Ontology
HyperlinkGene Summary
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. [provided by RefSeq
Other Designations
OTTHUMP00000061876|SMC1 (structural maintenance of chromosomes 1, yeast)-like 1|SMC1 structural maintenance of chromosomes 1-like 1|segregation of mitotic chromosomes 1
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Association of mammalian SMC1 and SMC3 proteins with meiotic chromosomes and synaptonemal complexes.
Eijpe M, Heyting C, Gross B, Jessberger R.
Journal of Cell Science 2000 Feb; 113(Pt 4):673.
Application：IF, WB-Ti, Rat, Spermatocytes, Testis.
-
Cloning and characterization of mammalian SMC1 and SMC3 genes and proteins, components of the DNA recombination complexes RC-1.
Stursberg S, Riwar B, Jessberger R.
Gene 1999 Mar; 228(1-2):1.
Application：IF, WB-Ti, Mouse, 70/Z3, Mouse tissues, Spleen cells.
-
SMC1: an essential yeast gene encoding a putative head-rod-tail protein is required for nuclear division and defines a new ubiquitous protein family.
Strunnikov AV, Larionov VL, Koshland D.
The Journal of Cell Biology 1993 Dec; 123(6 Pt 2):1635.
-
Association of mammalian SMC1 and SMC3 proteins with meiotic chromosomes and synaptonemal complexes.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com