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Last updated: 2016/12/4
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SMC1A monoclonal antibody, clone C2M

  • Catalog # : MAB2014
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against partial recombinant SMC1A.
  • Immunogen:
  • Recombinant protein corresponding to amino acids 402-894 of human SMC1A.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Isotype:
  • IgG
  • Quality Control Testing:
  • Antibody Reactive Against Recombinant Protein.
  • Recommend Usage:
  • Western blot (1 to 5 ug/mL)
    Immunofluorescence (5 to 10 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.08% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blotting using SMC1A monoclonal antibody, clone C2M (Cat # MAB2014) on HeLa cell lysate at 1 ug/mL .
  • Immunofluorescence
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunofluorescence
  • Gene Information
  • Entrez GeneID:
  • 8243
  • Gene Name:
  • SMC1A
  • Gene Alias:
  • CDLS2,DKFZp686L19178,DXS423E,KIAA0178,MGC138332,SB1.8,SMC1,SMC1L1,SMC1alpha,SMCB
  • Gene Description:
  • structural maintenance of chromosomes 1A
  • Gene Summary:
  • Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000061876,SMC1 (structural maintenance of chromosomes 1, yeast)-like 1,SMC1 structural maintenance of chromosomes 1-like 1,segregation of mitotic chromosomes 1
  • Gene Pathway
  • Related Disease
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