ARNT monoclonal antibody, clone EAD-1
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More Files
- More Functions
Western Blot (Tissue lysate)
Western Blot analysis of human fetal kidney tissue lysate with ARNT monoclonal antibody, clone EAD-1 (Cat # MAB20139).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human colon with ARNT monoclonal antibody, clone EAD-1 (Cat # MAB20139).
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of human ARNT.
Immunogen
A synthetic peptide corresponding to human ARNT.
Host
Rabbit
Theoretical MW (kDa)
86.636
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:500-1:2000)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction
Store at -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western Blot analysis of human fetal kidney tissue lysate with ARNT monoclonal antibody, clone EAD-1 (Cat # MAB20139).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human colon with ARNT monoclonal antibody, clone EAD-1 (Cat # MAB20139). -
Gene Info — ARNT
Entrez GeneID
405Protein Accession#
P27540Gene Name
ARNT
Gene Alias
HIF-1beta, HIF1B, HIF1BETA, TANGO, bHLHe2
Gene Description
aryl hydrocarbon receptor nuclear translocator
Omim ID
126110Gene Ontology
HyperlinkGene Summary
The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Three alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000032943|dioxin receptor, nuclear translocator|hypoxia-inducible factor 1, beta subunit
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Interactome
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