RIT2 monoclonal antibody, clone 27G2
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More Files
- More Functions
Western Blot (Transfected lysate)
Western blot analysis using RIT2 monoclonal antibody, clone 27G2 (Cat # MAB2012) on 293 cells expressing HA-tagged RIT1 (1) and HA-tagged RIT2 (2).
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant RIT2.
Immunogen
Recombinant protein corresponding to full length human RIT2.
Host
Mouse
Reactivity
Human, Mouse
Specificity
This antibody detects recombinant Rin protein. Does not cross-react with Rit protein.
Form
Liquid
Isotype
IgG2b
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
Western blot (0.5 to 1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 20 mM sodium phosphate buffer, 150 mM NaCl, pH 7.5 (50% glycerol, 3 mM sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis using RIT2 monoclonal antibody, clone 27G2 (Cat # MAB2012) on 293 cells expressing HA-tagged RIT1 (1) and HA-tagged RIT2 (2). -
Gene Info — RIT2
Entrez GeneID
6014Gene Name
RIT2
Gene Alias
RIBA, RIN, ROC2
Gene Description
Ras-like without CAAX 2
Omim ID
609592Gene Ontology
HyperlinkGene Summary
RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999 [PubMed 10545207]).[supplied by OMIM
Other Designations
GTP-binding protein Roc2|Ric-like, expressed in neurons
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Interactome
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Disease
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Publication Reference
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Rit, a non-lipid-modified Ras-related protein, transforms NIH3T3 cells without activating the ERK, JNK, p38 MAPK or PI3K/Akt pathways.
Rusyn EV, Reynolds ER, Shao H, Grana TM, Chan TO, Andres DA, Cox AD.
Oncogene 2000 Sep; 19(41):4685.
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Biochemical characterization of the Ras-related GTPases Rit and Rin.
Shao H, Kadono-Okuda K, Finlin BS, Andres DA.
Archives of Biochemistry and Biophysics 1999 Nov; 371(2):207.
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Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins.
Lee CH, Della NG, Chew CE, Zack DJ.
Journal of Neuroscience 1996 Nov; 16(21):6784.
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Rit, a non-lipid-modified Ras-related protein, transforms NIH3T3 cells without activating the ERK, JNK, p38 MAPK or PI3K/Akt pathways.
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