GCLC monoclonal antibody, clone ABBG-7
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of human GCLC.
Immunogen
A synthetic peptide corresponding to human GCLC.
Host
Rabbit
Theoretical MW (kDa)
72.766
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction
Store at -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of HepG2 cell lysate with GCLC monoclonal antibody, clone ABBG-7 (Cat # MAB20082). -
Gene Info — GCLC
Entrez GeneID
2729Protein Accession#
P48506Gene Name
GCLC
Gene Alias
GCS, GLCL, GLCLC
Gene Description
glutamate-cysteine ligase, catalytic subunit
Gene Ontology
HyperlinkGene Summary
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. The gene encoding the catalytic subunit encodes a protein of 367 amino acids with a calculated molecular weight of 72.773 kDa and maps to chromosome 6. The regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia. [provided by RefSeq
Other Designations
gamma-glutamylcysteine synthetase
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Interactome
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Pathway
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Disease
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