ERBB4 monoclonal antibody, clone HC-5
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More Files
- More Functions
Western Blot
Western Blot analysis of Lane 1: human brain tissue and Lane 2: MCF-7 cell lysates with ERBB4 monoclonal antibody, clone HC-5 (Cat # MAB20016).
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of human ERBB4.
Immunogen
A synthetic peptide corresponding to human ERBB4.
Host
Rabbit
Theoretical MW (kDa)
146.808
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Flow Cytometry (1:40)
Immunocytochemistry (1:50-1:200)
Immunoprecipitation (1:30)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction
Store at -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of Lane 1: human brain tissue and Lane 2: MCF-7 cell lysates with ERBB4 monoclonal antibody, clone HC-5 (Cat # MAB20016).Immunocytochemistry
Immunoprecipitation
Flow Cytometry
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Gene Info — ERBB4
Entrez GeneID
2066Protein Accession#
Q15303Gene Name
ERBB4
Gene Alias
HER4, MGC138404, p180erbB4
Gene Description
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
Omim ID
600543Gene Ontology
HyperlinkGene Summary
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq
Other Designations
avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4|receptor tyrosine-protein kinase erbB-4|tyrosine kinase-type cell surface receptor HER4|v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4|v-erb-a erythroblastic leukemia v
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Interactome
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Pathway
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Disease
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