EDNRB monoclonal antibody, clone AABI-5
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of human EDNRB.
Immunogen
A synthetic peptide corresponding to human EDNRB.
Host
Rabbit
Theoretical MW (kDa)
49.644
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunoprecipitation (1:50)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction
Store at -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of 293T cell lysate with EDNRB monoclonal antibody, clone AABI-5 (Cat # MAB20010).Immunoprecipitation
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Gene Info — EDNRB
Entrez GeneID
1910Protein Accession#
P24530Gene Name
EDNRB
Gene Alias
ABCDS, ETB, ETBR, ETRB, HSCR, HSCR2
Gene Description
endothelin receptor type B
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Three transcript variants encoding two different isoforms have been found for this gene. While both isoforms bind ET1, they exhibit different responses upon binding, suggesting that they may be functionally distinct. [provided by RefSeq
Other Designations
OTTHUMP00000178736|endothelin receptor non-selective type
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Interactome
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Pathway
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Disease
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