MITF monoclonal antibody, clone C5
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining usin MITF monoclonal antibody, clone C5 (Cat # MAB1955) on formalin fixed, paraffin embedded human melanoma.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant MITF.
Immunogen
Recombinant protein corresponding to N-terminus of human MITF.
Host
Mouse
Reactivity
Human, Mouse, Rat
Form
Liquid
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
Western blot (1 ug/mL)
Immunoprecipitation (2 ug/mg of protein lysate)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining usin MITF monoclonal antibody, clone C5 (Cat # MAB1955) on formalin fixed, paraffin embedded human melanoma.Immunohistochemistry (Frozen sections)
Immunoprecipitation
Gel Supershift Assay
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Gene Info — MITF
Entrez GeneID
4286Gene Name
MITF
Gene Alias
MI, WS2A, bHLHe32
Gene Description
microphthalmia-associated transcription factor
Gene Ontology
HyperlinkGene Summary
This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq
Other Designations
OTTHUMP00000195123|OTTHUMP00000195140|homolog of mouse microphthalmia
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Interactome
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Pathway
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Disease
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Publication Reference
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Age-resolving osteopetrosis: a rat model implicating microphthalmia and the related transcription factor TFE3.
Weilbaecher KN, Hershey CL, Takemoto CM, Horstmann MA, Hemesath TJ, Tashjian AH, Fisher DE.
The Journal of Experimental Medicine 1998 Mar; 187(5):775.
Application：ICC, IP, WB-Ce, Human, Mouse, Rat, B16, L, NIH/3T3 cells, Osteoclasts.
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MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes.
Hemesath TJ, Price ER, Takemoto C, Badalian T, Fisher DE.
Nature 1998 Jan; 39(6664):298.
Application：WB-Ce, Human, Melanoma cells.
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Age-resolving osteopetrosis: a rat model implicating microphthalmia and the related transcription factor TFE3.
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