SPTBN4 monoclonal antibody, clone S393-2 (PerCP)
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More Files
- More Functions
Western Blot
Western Blot analysis of COS-Beta-4-Spectrin-His.
Immunocytochemistry
Immunocytochemical staining of SK-N-BE cell line (A) DAPI (blue) nuclear stain, (B) Phalloidin Texas Red F-Actin stain, (C) SPTBN4 Antibody and (D) Composite.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human SPTBN4.
Immunogen
Recombinant protein corresponding to amino acids 1621-1832 at C-terminus repeats 14 to 15 of human Beta4-spectrin.
Host
Mouse
Reactivity
Human, Mouse, Rat
Specificity
This antibody detects ~>200kDa. Does not cross react with other Beta-spectrins.
Form
Liquid
Conjugation
PerCP
Purification
Protein G purification
Isotype
IgG1
Recommend Usage
Immunocytochemistry
Immunofluorescence
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (50% glycerol, 0.09% sodium azide).
Storage Instruction
Store at -20°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of COS-Beta-4-Spectrin-His.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunocytochemistry
Immunocytochemical staining of SK-N-BE cell line (A) DAPI (blue) nuclear stain, (B) Phalloidin Texas Red F-Actin stain, (C) SPTBN4 Antibody and (D) Composite.Immunofluorescence
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Gene Info — SPTBN4
Entrez GeneID
57731Protein Accession#
Q9H254Gene Name
SPTBN4
Gene Alias
KIAA1642, QV, SPNB4, SPTBN3
Gene Description
spectrin, beta, non-erythrocytic 4
Omim ID
606214Gene Ontology
HyperlinkGene Summary
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein localizes to the nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles. A highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
betaIV spectrin
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Interactome
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Disease
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