LEF1 monoclonal antibody, clone REMB1
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant LEF1.
Immunogen
Recombinant protein corresponding to full length LEF1.
Host
Mouse
Reactivity
Human, Mouse
Form
Liquid
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
Western blot (1 to 5 ug/mL)
Immunofluorescence on paraformaldehyde fixed cells (1:1000 or 1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis using LEF1 monoclonal antibody, clone REMB1 (Cat # MAB1943) on Jurkat cell lysate at 5 ug/mL .Immunohistochemistry
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Gene Info — LEF1
Entrez GeneID
51176Gene Name
LEF1
Gene Alias
DKFZp586H0919, TCF1ALPHA
Gene Description
lymphoid enhancer-binding factor 1
Omim ID
153245Gene Ontology
HyperlinkGene Summary
LEF1 is a nuclear protein that is expressed in pre-B and T cells. It binds to a functionally important site in the T-cell receptor-alpha (TCRA; MIM 186880) enhancer and confers maximal enhancer activity. LEF1 belongs to a family of regulatory proteins that share homology with high mobility group protein-1 (HMG1; MIM 163905) (Waterman et al., 1991 [PubMed 2010090]; van Genderen et al., 1994 [PubMed 7958926]).[supplied by OMIM
Other Designations
lymphoid enhancer binding factor-1
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Interactome
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Pathway
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Disease
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Publication Reference
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Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with beta-catenin.
Hsu SC, Galceran J, Grosschedl R.
Molecular and Cellular Biology 1998 Aug; 18(8):4807.
Application:IF, Mouse, NIH/3T3 cells.
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Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with beta-catenin.
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