MAD1L1 monoclonal antibody, clone 9B10
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant.
Immunogen
Recombinant protein corresponding to full length human MAD1L1.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG2b
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
Western Blot (1:200-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 20 mM KH2PO4, 150 mM NaCl, pH 7.2 (0.01% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — MAD1L1
Entrez GeneID
8379Protein Accession#
Q9Y6D9;NP_001013859Gene Name
MAD1L1
Gene Alias
HsMAD1, MAD1, PIG9, TP53I9, TXBP181
Gene Description
MAD1 mitotic arrest deficient-like 1 (yeast)
Gene Ontology
HyperlinkGene Summary
MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
MAD1 (mitotic arrest deficient, yeast, homolog)-like 1|MAD1-like 1 protein|mitotic-arrest deficient 1, yeast, homolog-like 1|tumor protein p53 inducible protein 9
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Interactome
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Pathway
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Disease
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Publication Reference
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Kinetochore structure and function.
Chan GK, Liu ST, Yen TJ.
Trends in Cell Biology 2005 Nov; 15(11):589.
Application：IF, WB, Human, Human mammalian cells.
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Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss.
Weaver BA, Bonday ZQ, Putkey FR, Kops GJ, Silk AD, Cleveland DW.
The Journal of Cell Biology 2003 Aug; 162(4):551.
Application：IF, Mouse, MEFs.
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Mitotic checkpoint proteins HsMAD1 and HsMAD2 are associated with nuclear pore complexes in interphase.
Campbell MS, Chan GK, Yen TJ.
Journal of Cell Science 2001 Mar; 114(Pt 5):953.
Application：EM, IF, IP, WB-Ce, Human, HeLa cells.
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Kinetochore structure and function.
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