ZAP70/SYK (phospho Y493/Y526) monoclonal antibody, clone H11 (PE)
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More Files
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Flow Cytometry
Flow cytometric analysis of Jurkat cells with ZAP70/SYK (phospho Y493/Y526) monoclonal antibody, clone H11 (PE) (Cat # MAB19169). Unstained cells negative control (blue) or stained and untreated (red) or treated with pervanadate (green).
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic phosphopeptide of human ZAP70/SYK.
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Y493 of human ZAP70.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Conjugation
PE
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (5 uL/106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.2% BSA, 0.09% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of Jurkat cells with ZAP70/SYK (phospho Y493/Y526) monoclonal antibody, clone H11 (PE) (Cat # MAB19169). Unstained cells negative control (blue) or stained and untreated (red) or treated with pervanadate (green). -
Gene Info — SYK
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Gene Info — ZAP70
Entrez GeneID
7535Gene Name
ZAP70
Gene Alias
FLJ17670, FLJ17679, SRK, STD, TZK, ZAP-70
Gene Description
zeta-chain (TCR) associated protein kinase 70kDa
Omim ID
176947Gene Ontology
HyperlinkGene Summary
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq
Other Designations
syk-related tyrosine kinase|zeta-chain (TCR) associated protein kinase (70 kD)|zeta-chain associated protein kinase 70kDa|zeta-chain associated protein kinase, 70kD
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Interactome
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Pathway
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Disease
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