STAT6 (phospho Y641) monoclonal antibody, clone G12 (FITC)
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More Files
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Flow Cytometry
Flow cytometric analysis of U937 cells with STAT6 (phospho Y641) monoclonal antibody, clone G12 (FITC) (Cat # MAB19154). Unstained cells negative control (blue) or stained and untreated (red) or treated with IFNa and IL-4 (green).
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic phosphopeptide of human STAT6.
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Y641 of human STAT6.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Conjugation
FITC
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (5 uL/106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.2% BSA, 0.09% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of U937 cells with STAT6 (phospho Y641) monoclonal antibody, clone G12 (FITC) (Cat # MAB19154). Unstained cells negative control (blue) or stained and untreated (red) or treated with IFNa and IL-4 (green). -
Gene Info — STAT6
Entrez GeneID
6778Gene Name
STAT6
Gene Alias
D12S1644, IL-4-STAT, STAT6B, STAT6C
Gene Description
signal transducer and activator of transcription 6, interleukin-4 induced
Omim ID
601512Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. [provided by RefSeq
Other Designations
STAT, interleukin4-induced|signal transducer and activator of transcription 6|transcription factor IL-4 STAT
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