STAT3 (phospho Y705) monoclonal antibody, clone B12 (FITC)
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More Files
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Flow Cytometry
Flow cytometric analysis of Jurkat cells with STAT3 (phospho Y705) monoclonal antibody, clone B12 (FITC) (Cat # MAB19128). Secondary antibody only negative control (blue) or untreated (red) or treated with IFNa, IL-4 and pervanadate (green).
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic phosphopeptide of human STAT3.
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Y705 of human STAT3.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Conjugation
FITC
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (5 uL/106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.2% BSA, 0.09% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of Jurkat cells with STAT3 (phospho Y705) monoclonal antibody, clone B12 (FITC) (Cat # MAB19128). Secondary antibody only negative control (blue) or untreated (red) or treated with IFNa, IL-4 and pervanadate (green). -
Gene Info — STAT3
Entrez GeneID
6774Gene Name
STAT3
Gene Alias
APRF, FLJ20882, HIES, MGC16063
Gene Description
signal transducer and activator of transcription 3 (acute-phase response factor)
Omim ID
102582Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq
Other Designations
DNA-binding protein APRF|acute-phase response factor|signal transducer and activator of transcription 3
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