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Last updated: 2020/11/29
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LCP2 (phospho Y128) monoclonal antibody, clone 3F8 (PE) 

  • Catalog # : MAB19092
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against synthetic phosphopeptide of human LCP2.
  • Immunogen:
  • A synthetic phosphopeptide corresponding to residues surrounding Y128 of human LCP2.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Conjugation:
  • PE
  • Purification:
  • Protein A/G Purification
  • Isotype:
  • IgG1k
  • Recommend Usage:
  • Flow Cytometry (5 uL/106 cells or 0.05 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (0.2% BSA, 0.09% sodium azide).
  • Storage Instruction:
  • Store at 2-8°C.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Flow Cytometry
  • Flow Cytometry
  • Flow cytometric analysis of Ramos cells unstained cells negative control (blue) or untreated (red) or treated with pervanadate (green) using LCP2 (phospho Y128) monoclonal antibody (PE).
  • Application Image
  • Gene Information
  • Entrez GeneID:
  • 3937
  • Gene Name:
  • LCP2
  • Gene Alias:
  • SLP-76,SLP76
  • Gene Description:
  • lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
  • Gene Summary:
  • SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function. [provided by RefSeq
  • Other Designations:
  • 76 kDa tyrosine phosphoprotein,SH2 domain-containing leukocyte protein of 76kD,lymphocyte cytosolic protein 2,lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kD)
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