LCP2 (phospho Y128) monoclonal antibody, clone 3F8 (FITC)
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Specifications
Product Description
Rabbit monoclonal antibody raised against synthetic phosphopeptide of human LCP2.
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Y128 of human LCP2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Conjugation
FITC
Purification
Protein A/G Purification
Isotype
IgG1k
Recommend Usage
Flow Cytometry (5 uL/106 cells or 0.05 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.2% BSA, 0.09% sodium azide).
Storage Instruction
Store at 2-8°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of Ramos cells unstained untreated cells as negative control (blue) or stained untreated (red) or treated with pervanadate (green) using LCP2 (phospho Y128) monoclonal antibody (FITC). -
Gene Info — LCP2
Entrez GeneID
3937Gene Name
LCP2
Gene Alias
SLP-76, SLP76
Gene Description
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
Omim ID
601603Gene Ontology
HyperlinkGene Summary
SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function. [provided by RefSeq
Other Designations
76 kDa tyrosine phosphoprotein|SH2 domain-containing leukocyte protein of 76kD|lymphocyte cytosolic protein 2|lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kD)
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Interactomes
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