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Last updated: 2020/11/29
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PTPN11 (phospho Y580) monoclonal antibody, clone 4A2 (PE) 

  • Catalog # : MAB19082
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against synthetic phosphopeptide of human PTPN11.
  • Immunogen:
  • A synthetic phosphopeptide corresponding to residues surrounding Y580 of human PTPN11.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Conjugation:
  • PE
  • Purification:
  • Protein A/G Purification
  • Isotype:
  • IgG1k
  • Recommend Usage:
  • Flow Cytometry (5 uL/106 cells or 0.05 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (0.2% BSA, 0.09% sodium azide).
  • Storage Instruction:
  • Store at 2-8°C.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Flow Cytometry
  • Flow Cytometry
  • Flow cytometric analysis of U937 cells unstained untreated cells as negative control (blue) or stained and untreated (red) or treated cells with IFNα IL4 and pervanadate (green) using PTPN11 (phospho Y580) monoclonal antibody (PE).
  • Application Image
  • Gene Information
  • Entrez GeneID:
  • 5781
  • Gene Name:
  • PTPN11
  • Gene Alias:
  • BPTP3,CFC,MGC14433,NS1,PTP-1D,PTP2C,SH-PTP2,SH-PTP3,SHP2
  • Gene Description:
  • protein tyrosine phosphatase, non-receptor type 11
  • Gene Summary:
  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq
  • Other Designations:
  • protein tyrosine phosphatase-2,protein-tyrosine phosphatase 2C
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