PTPN11 (phospho Y580) monoclonal antibody, clone 4A2
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More Files
- More Functions
Flow Cytometry
Flow cytometric analysis of U937 cells secondary antibody only negative control (blue) or untreated (red) or treated with IFNα IL4 and pervanadate (green) using PTPN11 (phospho Y580) monoclonal antibody.
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic phosphopeptide of human PTPN11.
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Y580 of human PTPN11.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A/G Purification
Isotype
IgG1k
Recommend Usage
Flow Cytometry (1 ug/mL - 0.001 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (50% glycerol, 0.02% sodium azide, 0.1% BSA).
Storage Instruction
Store at -20°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of U937 cells secondary antibody only negative control (blue) or untreated (red) or treated with IFNα IL4 and pervanadate (green) using PTPN11 (phospho Y580) monoclonal antibody. -
Gene Info — PTPN11
Entrez GeneID
5781Gene Name
PTPN11
Gene Alias
BPTP3, CFC, MGC14433, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
Gene Description
protein tyrosine phosphatase, non-receptor type 11
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq
Other Designations
protein tyrosine phosphatase-2|protein-tyrosine phosphatase 2C
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