PLCG2 (phospho Y759) monoclonal antibody, clone G3 (FITC)
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More Files
- More Functions
Flow Cytometry
Flow cytometric analysis of Hela cells unstained cells negative control (blue) or stained and treated with imatinib (red) or treated with pervanadate (green) using PLCG2 (phospho Y759) monoclonal antibody (FITC).
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic phosphopeptide of human PLCG2.
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Y759 of human PLCG2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Conjugation
FITC
Purification
Protein A/G Purification
Isotype
IgG1k
Recommend Usage
Flow Cytometry (5 uL/106 cells or 0.05 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.2% BSA, 0.09% sodium azide).
Storage Instruction
Store at 2-8°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of Hela cells unstained cells negative control (blue) or stained and treated with imatinib (red) or treated with pervanadate (green) using PLCG2 (phospho Y759) monoclonal antibody (FITC). -
Gene Info — PLCG2
Entrez GeneID
5336Gene Name
PLCG2
Gene Alias
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Gene Description
phospholipase C, gamma 2 (phosphatidylinositol-specific)
Omim ID
600220Gene Ontology
HyperlinkGene Summary
Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups. A number of these enzymes have specificity for phosphoinositides. Of the phosphoinositide-specific phospholipase C enzymes, C-beta is regulated by heterotrimeric G protein-coupled receptors, while the closely related C-gamma-1 (PLCG1; MIM 172420) and C-gamma-2 enzymes are controlled by receptor tyrosine kinases. The C-gamma-1 and C-gamma-2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic domains of the SRC oncogene product, SH2 and SH3.[supplied by OMIM
Other Designations
phospholipase C gamma 2|phospholipase C, gamma 2|phospholipase C, gamma 2 (phosphatidylyinositol-specific)
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Interactome
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Pathway
- B cell receptor signaling pathway
- Calcium signaling pathway
- Epithelial cell signaling in Helicobacter pylori infection
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Glioma
- Inositol phosphate metabolism
- Leukocyte transendothelial migration
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Disease
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