PLCG1 (phospho Y783) monoclonal antibody, clone C4 (SureLight 488)
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More Files
- More Functions
Flow Cytometry
Flow cytometric analysis of Hela cells unstained imatinib treated cells (blue) or stained treated with imatinib (red) or with pervanadate (green) using PLCG1 (phospho Y783) monoclonal antibody (SureLight 488).
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic phosphopeptide of human PLCG1.
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Y783 of human PLCG1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Conjugation
SureLight 488
Purification
Protein A/G Purification
Isotype
IgG1k
Recommend Usage
Flow Cytometry (5 uL/106 cells or 0.05 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.2% BSA, 0.09% sodium azide).
Storage Instruction
Store at 2-8°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of Hela cells unstained imatinib treated cells (blue) or stained treated with imatinib (red) or with pervanadate (green) using PLCG1 (phospho Y783) monoclonal antibody (SureLight 488). -
Gene Info — PLCG1
Entrez GeneID
5335Gene Name
PLCG1
Gene Alias
PLC-II, PLC1, PLC148, PLCgamma1
Gene Description
phospholipase C, gamma 1
Omim ID
172420Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
1-phosphatidyl-D-myo-inositol-4,5-bisphosphate|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1|OTTHUMP00000031787|OTTHUMP00000178982|PLC-gamma-1|inositoltrisphosphohydrolase|monophosphatidylinositol phosphodiesterase|phosphatidylinositol
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Interactome
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Pathway
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Disease
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